Knee osteoarthritis (KOA) is a disease mainly characterized by degenerative changes in articular cartilage, and its exact pathogenesis is currently unclear. Clinically, it is more common in the elderly, and its main manifestations are knee joint pain, limited mobility, and knee joint deformity. It is the type of osteoarthritis that has the greatest impact on the quality of life of the elderly. Current treatment methods mainly focus on improving symptoms, relieving pain, correcting deformities, and restoring joint function. There is no specific cure. Platelet-rich plasma (PRP) is a platelet concentrate separated from autologous blood by centrifugation. It is rich in a variety of growth factors and can play an important role in wound repair and healing. It is widely used in fields such as orthopedics and burn departments, pain department, oral and maxillofacial department. 

PRP is a concentration of platelets in autologous blood. The concentration of platelets is 3 to 5 times higher than that in plasma. It contains various types of bioactive proteins, cytokines, and anti-inflammatory mediators. Studies have shown that PRP has a strong positive promoting effect on chondrocyte proliferation, inflammation, and cell differentiation properties. In addition, PRP also contains neutrophils, monocytes, lymphocytes, etc., which can release a large number of growth factors after activation to promote tissue and cell repair. 

At present, there are many methods for preparing PRP, including preparation by blood apheresis, manual preparation by test tube method, special PRP kit preparation, standard blood bag preparation, etc. The quality of PRP collected using different preparation methods also varies. The manual preparation method is to collect the patient's blood for anticoagulation and centrifugation. The PRP is collected through one centrifugation and centrifuged again to further extract and concentrate the PRP. Due to its low cost, simplicity, and ease of operation, it was previously the most commonly used method, but it caused a large amount of blood loss and had a certain risk of contamination. This method is no longer recommended. The component blood apheresis preparation method has the advantages of higher PRP concentration, more stable and uniform components, short time, low probability of contamination, and high cost-benefit ratio. It has become the preferred recommended method by expert consensus and has been promoted in clinical practice and applications.

Increasing evidence shows that chondrocyte apoptosis and degradation play a key role in the physiological and pathological processes of osteoarthritis. Some studies have shown that PRP can promote cartilage repair and delay the progression of KOA. PRP intra-articular injection treatment is an invasive operation, and the principle of asepsis must be strictly followed during the operation. It is contraindicated to use if there are skin ulcers or infection at the injection site. Absolute contraindications for PRP in the treatment of KOA: sepsis, platelet dysfunction syndrome, thrombocytopenia, bleeding disorders, etc. 

KOA is a common orthopedic disease. Currently, there is no definite treatment method that can slow down the progression of the disease or restore the original structure and function of the damaged joint. Health education, establishing a reasonable daily routine, and changing lifestyle are key factors in preventing and treating arthritis. During the clinical diagnosis and treatment process, appropriate and specific treatment options are mainly selected based on the severity of KOA. Drug treatment (such as analgesics), intra-articular injection treatment, etc. are usually used for mild arthritis. However, due to its many side effects, such as gastrointestinal reactions, nausea, high blood pressure, etc., and its inability to delay the progression of the disease, long-term use is generally not recommended. Total knee replacement is a quick and effective solution. It is mainly used for patients with severe osteoarthritis, which seriously affects their lives and is unresponsive to medical treatment. Its long-term sustainability is poor, and the surgery will also cause relatively many problems for the patient. PRP is derived from autologous plasma. It is easy to obtain, convenient and quick to prepare. It has low incidence of blood infection, allergic reaction, and immune reaction. It has the characteristics of promoting cartilage repair and anti-inflammatory response. Multiple research evidence also shows that intra-articular injection is highly safe and effective. Its efficacy is supported by clinical evidence-based medicine. Compared with surgery, PRP treatment causes less secondary damage to the knee joint and is more conducive to the repair of the knee joint. Based on these advantages, PRP is also widely used in other fields. As the research on PRP continues to deepen, the shortcomings of PRP will be made up, and its prospects for the treatment of KOA are also promising in the future.

Platelet Rich Plasma (PRP) Preparation Kit

>Fully automatic；
>Platelet concentration is adjustable 2-8 times；
>Safe and reliable；
>Preparation only takes 15 minutes；
>Leukocyte-poor/rich PRP optional；
>Personalized diagnosis and treatment

Application:
Orthopedic(Osteoarthritis; Microfracture surgery; Chronic osteomyelitis)
Rehabilitative Medicine(Meniscal injuries; Rotator cuff injuries; Tennis elbow)
Wound repair(Diabetic foot; Burns; Scalds)
Gynecology(Infertility; Endometrial repair; Improvement of ovarian function)
Plastic and Reconstructive Surgery(Anti-aging; Pigmentation; Alopecia areata)
Others(Surgical incisions; Tooth extractions; Dry eye syndrome)